Scientific Contributions

Peer Reviewed:

• Wenyun Lu, Noel R. Park, Tara TeSlaa, Connor S.R. Jankowski, Laith Samarah, Melanie McReynolds, Xi Xing, Jessica Schembri, Morgan T. Woolf, Joshua D. Rabinowitz, and Shawn M. Davidson. Acidic Methanol Treatment Facilitates Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging of Energy Metabolism. (2023). Analytical Chemistry. DOI: https://doi.org/10.1021/acs.analchem.3c01875
• Link: https://pubs.acs.org/doi/full/10.1021/acs.analchem.3c01875

• Murphy, A.C., McReynolds, M.R. Toying with reductive stress. (2023). Nat Chem Biol. DOI: https://doi.org/10.1038/s41589-023-01461-9
• Link: https://www.nature.com/articles/s41589-023-01461-9

• Neikirk, K., Ume, A. C., Prasad, P., Marshall, A. G., Rockwood, J., Wenegieme, T.-Y., McMichael, K. E., McReynolds, M. R., Williams, C. R., & Hinton, A. Jr. (2023). Latent transforming growth factor beta binding protein 4: A regulator of mitochondrial function in acute kidney injury. Aging Cell, 22, e14019. DOI: https://doi.org/10.1111/acel.14019
• Link: https://onlinelibrary.wiley.com/doi/full/10.1111/acel.14019

• Kelly A. Hogan, Julianna D. Zeidler, Heather K. Beasley, Abrar I. Alsaadi, Abdulkareem A. Alshaheeb, Yi-Chin Chang, Hua Tian, Antentor O. Hinton Jr, Melanie R. McReynolds. Using mass spectrometry imaging to visualize age-related subcellular disruption. Front. Mol. Biosci., 08 March 2023. Sec. Cellular Biochemistry. DOI: https://doi.org/10.3389/fmolb.2023.906606
• Link: https://www.frontiersin.org/articles/10.3389/fmolb.2023.906606/full

• Rosina Comas-Ghierra, Abdulkareem Alshaheeb, Melanie R. McReynolds, Jennifer N. Shepherd, and Gustavo Salinas. Antioxidants & Redox Signaling. A Minimal Kynurenine Pathway Was Preserved for Rhodoquinone but Not for De Novo NAD⁺ Biosynthesis in Parasitic Worms: The Essential Role of NAD⁺ Rescue Pathways. DOI: https://doi.org/10.1089/ars.2023.0293
• Link: https://www.liebertpub.com/doi/abs/10.1089/ars.2023.0293
  

• Chellappa, K.*, McReynolds, M.R*., Lu, W. Zeng, X., Makarov, M., Hayat. F., Mukherjee, S., Bhat, Y.R. Lingala, S.R., Shima, R.T., Descamps, H.C, Cox, T., Ji, L., Jankowski, C., Chu, Q., Davidson, S.M., Thaiss, C.A., Migaud, M.E., Rabinowitz, J.D., and J.A. Baur. NAD precursors cycle between host tissues and the gut microbiome. (2022). Cell Metabolism. DOI: https://doi.org/10.1016/j.cmet.2022.11.004 
• Link: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00495-8

• Wang, L., Xing, X., Zeng,X., Jackson, S.R., TeSlaa, T., Al-Dalahmah, O., Samarah, L.Z. Goodwin, K., Yang, L., McReynolds, M.R., Li, X., Wolff, J.J., Rabinowitz, J.D., and S.M. Davidson. Spatially resolved isotope tracing reveals tissue metabolic activity. (2022). Nature Methods. DOI: https://doi.org/10.1038/s41592-021-01378-y
• Link: https://www.nature.com/articles/s41592-021-01378-y

• Calantone, N., Kayode, Y., McReynolds, M.R., Clemmer, D.C., Hudson, H., Clerc, I., Hong, H.K., Brenchley, J.M., Bass, J., D’Aquila, R.T., and H.E. Taylor. mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses. (2022). Commun Biol. https://doi.org/10.1038/s42003-022-03804-z
• Link: https://www.nature.com/articles/s42003-022-03804-z

• Lengefeld, J., Cheng, C.W., Maretich, P., Blair, M., Hagen, H., McReynolds, M.R., Sullivan, E., Mayors, K., Roberts, C., Kang, J.K., Steiner, J., Miettinen, T.P., Manalis, S.R., Antebi, A., Rabinowitz, J.D., Morrison, S., Lees, J.A., Boyer, L., Yilmaz, O., and A. Amon. Cell size is a determinant of stem cell potential during aging. (2021). Science Advances. https://doi.org/10.1101/2020.10.27.355388
• Link: https://www.science.org/doi/abs/10.1126/sciadv.abk0271

• Chen, L., Lu, W., Wang, L., Xing, X., Zeng, X., Muscarekka, A.D., Shen, Y., Cowan, A., McReynolds, M.R., Kennedy, B., Lato, A.M., Campagna, S.R., Singh, M., and J.D. Rabinowtiz. (2021). Metabolite discovery through global annotation of untargeted metabolomics data. Nature Methods. https://doi.org/10.1038/s41592-021-01303-3
• Link: https://www.nature.com/articles/s41592-021-01303-3

• McReynolds, M.R., Chellappa, K., Chiles, E., Jankowski, C., Shen, Y., Chen, L., Descamps, H.C., Mukherheem S., Bhat, Y.R., Lingala, S.R., Chu, Q., Botolin, P., Hayat, F., Doke, T., Susztak, K., Thaiss, C.A., Lu, W., Migaud, M.E., Su, X., Rabinwoitz, J.D., and J.A. Baur. (2021). NAD+ flux is maintained in aged mice despite lower tissue concentrations. Cell Systems. https://doi.org/10.1016/j.cels.2021.09.001
• Link: https://www.sciencedirect.com/science/article/pii/S2405471221003380 

• Schild, T., McReynolds, M.R., Shea, C., Low, V., Asara, J., Dephoure, N., Rabinowitz, J.D., Gomes, A.P. and J. Blenis. (2021). NADK is activated by oncogenic KRAS signaling to sustain pancreatic ductal adenocarcinoma. Cell Reports. https://doi.org/10.1016/j.celrep.2021.109238 
• Link: https://www.sciencedirect.com/science/article/pii/S2211124721005970

• Minhas, P., Hernandez, A.L.*, McReynolds, M.R.*, He, J., Joshi, A., Linde, M., Wilson, E.N., Rubin, A.J., Wang, Q.A., Swarovski, M., Majeti, R., Mochly-Rosen, D.R., Weissman, I., Longo, F.M., Rabinowitz, J.D. and K.I. Andreasson. (2020). Restoring metabolism oof myeloid cells reverses cognitive decline in ageing. Nature. https://doi.org/10.1038/s41586-020-03160-0
• Link: https://www.nature.com/articles/s41586-020-03160-0?from=article_link

• Luonogo, T.S., Eller, J.M., Lu, M.J., Niere, M., Raith, F., Perry, C., Bornstein, M.R., Oliphint, P., Wang, L., McReynolds, M.R., Migaud, M.E., Rabinowitz, J.D., Johnson, F.B., Johnsson, K., Ziegler, M., Cambronne, X.A., and J.A. Baur. (2020). SLC25A51 is a mammalian mitochondrial NAD transporter. Nature. https://doi.org/10.1038/s41586-020-2741-7
• Link: https://www.nature.com/articles/s41586-020-2741-7

• Chini, C.S., Tarrago, M.G., Warner, G.M., de Oliveira, G.C., Espindola-Netto, J.M., Puranik, A.S., Kashyap, S., Peclat, T.R., Dang, K., Clarke, S., Childs, B.G., Hogan, K.A., Kanamori, K.S., Witte, M.A., Vidal, P., Chellappa, K., McReynolds, M.R., Jankowski, C., Tchkonia, T., Kirkland, J.L., van Deursen, J.M., Baker, D.J., Cohen, R., van Schooten, W., Rabinowitz, J.D., Baur, J.A and E.N. Chini. (2020). Expression of the ecto-enzymes CD38 is induced by senescent cells and decreases tissues NAD⁺ during aging by depleting its precursor NMN. Nature Metabolism. https://doi.org/10.1038/s42255-020-00298-z
• Link: https://www.nature.com/articles/s42255-020-00298-z?elqTrackId=3446a43d0949433285a03746cd30839a

• Lu, W., Xing, X., Wang, L., Chen, L., Zhang, S., McReynolds, M.R. and J.D. Rabinowitz. (2020). Improved annotation of untargeted metabolomics data through buffer modifications that shift adduct mass and intensity. Analytical Chemistry. DOI: 10.1021/acs.analchem.0c00985
• Link: https://pubs.acs.org/doi/abs/10.1021/acs.analchem.0c00985

• Yang, L., Garcia-Canaveras, J.C., Chen, Z., Wang, L., Liang, L., Jang, C., Mayr, J.A., Zhang, Z., Ghergurovich, J.M., Zhan, L., Joshi, S., Hu, Z., McReynolds, M.R., Su, X., White, E., Morscher, R.J., and J.D. Rabinowitz. (2020). Serine catabolism feeds NADH when respiration is impaired. Cell Metabolism. DOI: 10.1016/j.cmet.2020.02.017
• Link: https://www.sciencedirect.com/science/article/pii/S1550413120301145

• McReynolds, M.R., Chellappa, K. and J.A. Baur. (2020). Age-related NAD⁺ decline. Experimental Gerontology. DOI: 10.1016/j.exger.2020.110888
• Link: https://www.sciencedirect.com/science/article/abs/pii/S0531556520300231

• McReynolds, M.R., Wang, W., Holleran, L.M. and W. Hanna-Rose. (2017). Uridine monophosphate synthetase enables eukaryotic de novo NAD⁺ biosynthesis from quinolinic acid. JBC. C117. 795344. DOI: 10.1074/jbc.C117.795344
• Link: https://www.sciencedirect.com/science/article/pii/S0021925820369891

• Ozcelik, A., Nama, N., Huang, PH., Kaynak, M., McReynolds, MR., Hanna-Rose, W., Huang, TJ. (2016). Acoustofluidic rotational manipulation of cells and organisms using oscillating solid structures. SMALL. DOI: 10.1002/smll.201601760
• Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201601760

• Wang W., McReynolds M.R., Gonvalves, J.F., Shu, M., Dhondt, I., Braeckman, B.P., Lange, S.E., Kho, K. Detwiler, A.C., Pacella, M.J. and W. Hanna-Rose. (2015). Comparative metabolomic profiling reveals that dysregulated glycolysis stemming from lack of salvage NAD⁺ biosynthesis impairs reproductive development in C. elegans” J. Bio. Chem. 2015, 290:26163-26179.
• Link: https://www.sciencedirect.com/science/article/pii/S0021925820495936

• Crook, M., McReynolds, M., Wang, W., Hanna-Rose, W. (2014). An NAD⁺ Biosynthetic Pathway Enzyme Functions Cell Non-Autonomously in C. elegans Development. Developmental Dynamics. 243:965-967.
• Link: https://anatomypubs.onlinelibrary.wiley.com/doi/abs/10.1002/dvdy.24139