We are currently living in the midst of a global pandemic—facing internal loses, economic hardships, and obscure dietary options—not to mention the numerous environmental pollutants we encounter daily. Therefore, it is quite hard to avoid the common stressors of daily life. How will these stressors disrupt and impact metabolic rates with age over the next 50 years? We hypothesize metabolic syndrome coupled to stress is a key vulnerability during aging. Our long-term goals are to uncover how external stressors create metabolic shock and vulnerability with age—triggering age-associated diseases and decline. These studies will substantially illuminate metabolic activity and how it changes during stress-induced aging. The results are expected to have a direct translational impact by (i) identifying novel targets and biomarkers that will accelerate the development of nutrient-based therapeutics and (ii) establishing the link between stress, aging and specific metabolic fluxes, thereby guiding efforts to ameliorate aging by enhancing modulating metabolism.